Unveiling the Therapeutic Potential of Cochlospermum tinctorium A Rich. (Bixaceae): A Biochemical Study

C. J. Ndouyang *

Département de Génie Agricole et de Sécurité Alimentaire, FSVT, Université de Pala, BP 20 Pala, Chad.

G. Kaptso

Département des Sciences Alimentaires et Nutrition, ENSAI, Université de Ngaoundéré, B.P. 455 Ngaoundéré, Cameroon.

R. M. Nguimbou

Département des Sciences Alimentaires et Nutrition, ENSAI, Université de Ngaoundéré, B.P. 455 Ngaoundéré, Cameroon.

C. Gaiani

Laboratoire d’Ingénierie des Biomolécules (LIBios), Nancy-University, 2 avenue de la Forêt de Haye B.P. 172 F-54505 Vandoeuvre-lès-Nancy, France.

J. Scher

Laboratoire d’Ingénierie des Biomolécules (LIBios), Nancy-University, 2 avenue de la Forêt de Haye B.P. 172 F-54505 Vandoeuvre-lès-Nancy, France.

T. Abdesalam

Département de la Santé Publique, Faculté des Sciences de la Santé Humaine, Université de N’Djaména, B.P. 1027, N’Djaména, Chad.

M. Mbaiguinam

Département de Biologie, Faculté des Sciences Exactes et Appliquées, Université de N’Djaména, B.P. 1027 N’Djaména, Chad.

*Author to whom correspondence should be addressed.


Abstract

Cochlospermum tinctorium A. Rich. (Bixaceae) is a widespread herbaceous plant in the African Sahelian and Sudanian zones. Its root is used as a food and medicinal plant. This research aimed to use the C. tinctorium root as an efficient medicinal vegetable organ. The factors of hepatic diseases are multiple, and developing a single agent capable of preventing hepatic diseases at all times appears elusive. Finding a potent drug that can regenerate hepatic functions irrespective of the initial cause of the damage appears more feasible by using C. tinctorium. Studies of parameters were realised according to standard laboratory methods. At a threshold of \(\alpha\) = 0.05, significant correlations (p < 0.05) were found between secondary metabolite contents and functional activities such as radical scavenging activity of antioxidant component or hydroxyl radical scavenging activity. The value of DPPHH (1,1-diphenyl-2-picryl-hydrazyl) was 95.56 ± 0.94% for Cochlospermum tinctorium (CT) inner Matrix, with a variation of 0.12% for CT Soaked inner Matrix and 1.63% for CT Peeler. But Hydroxyl Radical Scavenging Activity (HRSA) was 37.14 ± 5.71 for CT inner Matrix, with a variation of -38.46% for CT Soaked inner Matrix and -71.79% for CT Peeler. Free radicals and other reactive species are thought to play an important role in many human diseases. Radical scavenging activities are very important due to the deleterious role of free radicals in biological systems. Cochlospermum tinctorium root has exhibited efficiency in healing many diseases thanks to multiple bioactive compounds. In addition, the colour of powders depended on chemical compounds. Finally, Cochlospermum tinctorium root was found to neutralise organic radicals and reactive oxygen species. The ability of C. tinctorium root extract to give hydrogen to neutralise free radicals enhances its application in multiple ways, such as treatments of hepatitis or in biochemical reactions, i.e., chelating of free radicals. Meanwhile, further investigations are necessary to facilitate the usage of the C. tinctorium, even combined with other medicinal vegetables.

Keywords: Cochlospermum tinctorium, CT inner matrix, malaria, toxicity


How to Cite

Ndouyang, C. J., Kaptso, G., Nguimbou, R. M., Gaiani, C., Scher, J., Abdesalam, T., & Mbaiguinam, M. (2026). Unveiling the Therapeutic Potential of Cochlospermum tinctorium A Rich. (Bixaceae): A Biochemical Study. Research Perspective on Biological Science Vol. 12, 1–22. https://doi.org/10.9734/bpi/rpbs/v12/3795