https://stm2.bookpi.org/RDNAIRDFB <p>Dear Reader, at the outset, I thank you for buying, downloading/accessing the book and showing interest in reading its contents. I am introducing myself as Dr. Kiran Kumar H.B.PhD (Independent researcher affiliated to Nrupathunga University, the main author of the book, who, along with other co-authors, compiled the Book on RE-DNA and its role in diverse aspects of Biology. The Book is the outcome of my updates and keeping abreast of various developments in Repetitive DNA (RE) over the last 25 years. Scan, review of research papers few discussions (formal and informal) and initial drafts ultimately took shape over 2 to 3 months as the Book. Starting from my initial tryst with “Junk DNA” to analyse genomes of domesticated and wild silkworms as an MSc Project. Subsequent to this I used several DNA investigation methods as part of my PhD and PDF (NIMHANS, CANADA) in Human Genetics, of which repetitive DNA were a major part (Linkage mapping, screening of Neurological diseases, Ataxia, Schizophrenia, Autism). Since, 2 years, I have used <em>in silico</em> tools with respect to RE and contributed to several research papers in Biology in varied lines of enquiry, such as protein evolution, DNA-drug interaction, promoter dynamics, to name a few. As someone who is following the developments in genomics, including mega global projects Encode, 1000 Genomes, Denosovian mapping, along with big data and allied overlapping topics of relevance to the field, it was natural to compile diverse literature into a Book to give the reader a flavour of the role of RE in biology.</p> <p>Since the co-authors are from diverse areas of interest and expertise, viz., Zoology, Microbiology, Plant Biotechnology, Biochemistry, Biotechnology and a few in the company, we were able to gather literature on contemporary and relevant topics of interest to the science community. Coupled to the above motive, a desire to serve the temples of knowledge (University, Colleges) is also tagged as described in Indian spiritual literature. A logical progression ensued and took shape as the present Book. The efforts were aided by the almighty and the blessings of the Gurus.</p> <p>The Book is a resource for college and university students and professors. It is a quick brief and update to researchers in the area of Repetitive DNA, also researchers in the Plant, animal and microbial fields who are presently using RE and associated methods in their investigations. Since a few sections may appear a bit detail to ordinary readers, like College and university students.I am sure a bit of extra patient reading will give them an overview of the emerging and existing areas of Biology. Time and sincere efforts have been invested to create a few illustrative models to highlight the themes of the chapters. These can be used for teaching purposes.</p> <p>I place on record the authors and kind-hearted individuals to voluntarily contributed towards publication. A word of thanks to the hospitality and resources of my present homeowner for a calm and hygienic environment to enable the final product. I would also like to thank all affiliated faculty of the centres associated with the discussion and suggestions.</p> <p>Obescience to the almighty bhagavan for the initiation, keeping me motivated from start to end and eventual publications. The blessings of Gurus of sringeri peetam have showered its grace to re-structure resalign and present it a better format. I wouldn’t have completed it amidst multiple intermissions.</p> <p>Thank the blessings of my ancesters and late parents, relatives and well-wishers.</p> <p>No individual is perfect or book complete; hence I encourage readers to send positive feedbacks which will help me better in my future efforts</p> en-US Wed, 06 Aug 2025 00:00:00 +0000 OJS 3.3.0.10 http://blogs.law.harvard.edu/tech/rss 60 https://stm2.bookpi.org/RDNAIRDFB/article/view/269 <p>‘‘C-value paradox’’ or ‘‘C-value enigma’’, has intrigued biologists for over half a century. Rapid advances in DNA sequencing are now providing compelling evidence showing that variation in DNA amount arises predominantly from differences in the frequency of polyploidy, abundance of non-coding repetitive DNA and the dynamics of the processes that amplify, erode and delete DNA. Repetitive elements (REs) comprise large proportions of eukaryotic genomes and are fundamental to the evolutionary process. REs can be classified as interspersed or tandem repeats. Interspersed repeats include transposable elements (e.g., retrotransposons), which encode proteins that facilitate their movement and proliferation in genomes. Tandem repeats (e.g., satellite DNAs) can form large blocks (e.g., megabases) of relatively short non-coding sequences in repeated arrays. Together, interspersed and tandem repeats comprise a major fraction of the prokaryotic and eukaryotic genomes.</p> <p>REs exhibit an array of structural and evolutionary effects on genome evolution across species. TEs can be associated with genome rearrangement through various mechanisms, such as de novo TE insertion, TE insertion-mediated deletion, and homologous recombination between them. These rearrangements increase the genomic difference between genomes, and some specific rearrangements may lead to complex diseases. TEs transpose and insert themselves between genes; they can disrupt gene order, create gene duplications, or cause gene deletions. These structural changes can have significant effects on the organisation and function of the genome. Also, through recombination, TEs can serve as recombination sites in the genome, promoting genomic rearrangements. Recent studies reveal that chromosome-specific repetitive elements and small RNA-based chromatin regulation have been repeatedly adapted to guide epigenetic regulation of a chromosome. In the present book, we explore several aspects of Repetitive DNA ranging from chromosome to transcriptional regulation. At the chromosomal level roles of RE in Centromere organisation, histone and kinetochore dynamics evolution, viability and degeneration are reviewed using representative examples. Epigenetic and roles of repetitive DNA in human diseases have been recognised as niche areas by researchers furthering the role of RE in gene regulation, sex chromosome differentiation, are its major contribution to genomes.</p> Kiran Kumar Halagur Bhoge Gowda Copyright (c) 2025 Author(s). The licensee is the publisher (BP International). https://stm2.bookpi.org/RDNAIRDFB/article/view/269 Wed, 06 Aug 2025 00:00:00 +0000