Chronotherapy: Unleashing the Precision of Time for Enhanced Treatment Strategies
Subham Kumar Panda *
Department of Reproductive and Developmental Toxicology, Vipragen Biosciences Private Limited, 67B, Hootagalli Industrial Area, Mysuru, Karnataka, India.
V. G. S. Sharma
Department of Preclinical Toxicology, Vanta Bioscience Limited, SIPCOT Industrial Complex, Gummidipundi, Tamil Nadu, India.
B. Ray
Nityananda College of Pharmacy (Unit of B.C.E.T.), Balasore, India.
Aditya Kumar Jena
Nityananda College of Pharmacy (Unit of B.C.E.T.), Balasore, India.
*Author to whom correspondence should be addressed.
Abstract
Chronotherapy is an emerging discipline in medicine that emphasises aligning drug administration with the body’s inherent biological rhythms, particularly the circadian clock. Recognising that critical physiological functions such as hormone secretion, enzymatic activity, and metabolism fluctuate throughout the day, chronotherapy aims to enhance therapeutic efficacy and reduce adverse effects by synchronising treatment timing with these natural cycles. Recent progress in this field includes the development of time-specific drug formulations and advanced delivery systems, as well as computational tools and algorithms designed to tailor treatment regimens to individual patients. Although still evolving, chronotherapy holds significant promise for optimising clinical outcomes and advancing personalised medicine. The present study focuses on different aspects of Chronotherapy. This study explored the recent advances in chronotherapy, highlighting the potential it holds for revolutionising healthcare. Further research is required to fully understand the intricate mechanisms underlying chronotherapy and to explore its application across various medical conditions.
Keywords: Chronotherapy, chrono-pharmacology, chrono-pharmaceutics, biological rhythms, suprachiasmatic nuclei