Newer Frontiers in Urology, Volume III

Background: Female urethral stricture disease (FUSD) is an uncommon yet increasingly recognised cause of bladder outlet obstruction (BOO) in women that has long been obscured by heterogeneous definitions and overlap with “female urethral syndrome”. Women typically present with mixed lower urinary tract symptoms (LUTS) such as thin stream, hesitancy, straining, prolonged voiding, incomplete emptying, dysuria, and recurrent urinary tract infection, most often alongside frequency, urgency, nocturia, or incontinence.

Methodology and diagnostic approach: Diagnosis rests on a synthesis of clinical examination, uroflowmetry and post-void residual urine estimation, imaging, and endoscopy. Video-urodynamics is reserved for dilemmas separating BOO from detrusor underactivity.

Surgical management: Endoscopic dilation or direct vision internal urethrotomy (DVIU) is widely accessible but provides only short-term relief with high recurrence, especially after repeated procedures. Definitive management is reconstructive. Technique selection flap-based (vaginal or labial) versus graft-based (buccal or lingual oral mucosa, vaginal or labial mucosa) is guided by stricture site, length, tissue quality, and aetiology. Dorsal onlay buccal mucosal graft (BMG) urethroplasty, exploiting the vascular support of the clitoral cavernosal tissues and reducing fistula risk, has become the workhorse for many mid and proximal strictures. Ventral inlay/onlay approaches are valuable for distal disease or limited dorsal exposure, and double-face grafting is reserved for obliterative or recurrent cases.

Outcomes: Contemporary series consistently demonstrate ≥80% success with substantial improvements in flow and residual volumes, high satisfaction, and preserved continence. Risk factors for failure include longer strictures, prolonged symptom duration, multiple prior dilations, and lichen sclerosus.

Conclusion: This review systematises the diagnostic algorithm, urodynamic evaluation and modern reconstructive techniques for FUSD, addressing a critical gap in the literature and advocating the need for prospective, multi-centre trials with standardised definitions and quality of life endpoints.