Intraventricular Infusion Strategies for the Treatment of Alzheimer’s Disease: A Review
Terry Lichtor *
Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA.
*Author to whom correspondence should be addressed.
Abstract
The present study highlights about Intraventricular Infusion Strategies for the Treatment of Alzheimer’s Disease. Alzheimer’s disease is the most common neurodegenerative disorder. Currently available therapies have limited symptomatic efficacy and do not alter disease progression. Immunotherapeutic approaches using anti-Aβ antibodies injected systemically have shown some reduction in amyloid plaques but are associated with several side effects. Intraventricular delivery methods for direct intracerebral delivery of antibodies against amyloid plaques are being developed with significant therapeutic potential without the complications seen with systemic infusions. The intraventricular infusion strategy should avoid the complications observed with intravenous infusion of antibodies against Aβ which include dermatitis, pulmonary edema, allergic/anaphylactic reactions, acute renal failure, venous thrombosis and aseptic meningitis.
Keywords: Alzheimer’s disease, immunotherapy, intraventricular infusion