Water-Based Synthesis of 2-Hydrazinobenzothiazoles: An Improved Approach
Karan Singh *
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.
Manish Kumar
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.
Nehal Sagwal
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.
Kiran
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.
Sunil Kumar
Department of Physics, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.
*Author to whom correspondence should be addressed.
Abstract
A novel, eco-friendly synthesis of 2-hydrazinylbenzo[d]thiazoles via the reaction of benzo[d]thiazol-2-amines with hydrazine hydrate in water under reflux has been reported in this book chapter. This method demonstrates broad substrate scope, accommodating various electron-donating and withdrawing groups, and efficiently yields the corresponding 2-hydrazinobenzothiazole derivatives. The aqueous-based approach highlights the method's potential for green chemistry, making it an appealing strategy for synthesising diverse heterocycles such as hydrazones, pyrazoles, pyrazolines, triazoles, and others.
Keywords: Water-based synthesis, benzothiazole derivatives, therapeutic potential, chalcone derivatives, heterocycles