Copper-Mediated Cross Coupling Reactions and Their Applications: An Overview
Gadamani Suresh Babu *
Department of Humanities & Sciences, Brilliant Institute of Engineering & Technology, Abdullapur (V), Abdullapurmet (M), R.R District-501505, India.
Kiran Kumar Tatapudi
Discovery Analytical R&D Department, Aragen Life Sciences Pvt. Ltd., IDA Nacharam, Hyderabad, Telangana, India.
Surinderpal Singh
Department of Chemistry (H&S), CMR Engineering College, Kandlakoya (V), Medchal Road, Hyderabad, Telangana 501401, India.
Tiruveedhula Somasekhar
Department of Humanities & Sciences, Vidya Jyothi Institute of Technology, Aziz Nagar Gate, Chilkur Balaji Road, Himayat Sagar Rd, Hyderabad, Telangana 500075, India.
Hemambika Sadasivuni
Department of Freshmen Engineering, St. Martin’s Engineering College, Dhulapally, Hyderabad, Telangana-500100, India.
S. Ratna Kumari
Department of Chemistry, Basic Science & Humanities, Vignan's Nirula Institute of Technology and Science for Women, Guntur, A.P., India.
S N Murthy Boddapati *
Department of Chemistry, Sir C R Reddy College, Eluru, Andhra Pradesh-534007, India.
*Author to whom correspondence should be addressed.
Abstract
Copper (Cu) is a promising catalytic metal for C–C bond construction through coupling transformations. Coupling strategies of a range of organo-metallic reagents, with aromatic, heteroaromatic, and alkyl halides, can be carried out by Cu-catalysts with high efficiency, demonstrating the adaptability of Cu supported catalytic methods in carrying out these transformations. Conversely, the parallel palladium-catalysed cross-coupling methods are frequently complementary to the scope and selectivity of copper-assisted methods. Furthermore, Cu-catalysts are displaying a distinct pattern of reactivity that permits ligand-less coupling for the formation of aromatic–heteroaromatic and heteroaromatic–heteroaromatic bonds, a transformation that typically calls for unique, specially created ligands with Pd-catalysts. Early findings in the field of Cu-mediated couplings to generate C-C bonds are summarised in this chapter.
Keywords: Catalysts, C-C bonds, heteroaromatic, copper