Chemistry and Biochemistry: Research Progress Vol. 9

Substituted Arylidene Imidazolones: Synthesis, Spectral Characterization and Molecular Docking Studies

Y. Aparna *

Matrusri Engineering College, Saidabad, Hyderabad, Telangana, India.

N. J. P. Subhashini

Department of Chemistry, Osmania University, Hyderabad, Telangana, India.

*Author to whom correspondence should be addressed.

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Abstract

Ten analogues of acetylphenyl tethered imidazolones (4.12a-j) from 4-arylidene-2-phenyloxazol-5(4H)-ones were prepared and characterised by IR, ¹HNMR, ¹³CNMR and mass spectra. All the analogues have shown moderate to good antibacterial activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus. By means of FabI of S. aureus, docking studies were carried out. Altogether, the compounds were proven to be inhibitors of enoylacylcarrier proteinreductase.

Keywords: Imidazolinone derivatives, antibacterial activity, zone of inhibition, dockscore, synthesis

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